ParkinsonCanadaV1, Main, Exploration, bibRecord, 004D19

Exposure to cigarette smoke does not decrease the neurotoxicity of N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

Identifieur interne : 004D19 ( Main/Exploration ); précédent : 004D18; suivant : 004D20

Exposure to cigarette smoke does not decrease the neurotoxicity of N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

Auteurs : Thomas L. Perry [Canada] ; Shirley Hansen [Canada] ; Karen Jones [Canada]

Source :

Neuroscience Letters [ 0304-3940 ] ; 1987.

RBID : ISTEX:332AC72C922B4212ABDCA4670C8F3F5C768EAF88

Descripteurs français

Pascal (Inist)
- Cigarette, Fumée, Interaction toxique, MPTP, Modèle animal, Neurotoxine, Parkinson maladie, Pyridine(méthyl-1 phenyl-«4» tetrahydro-«1,2,3,6»), Souris, Système nerveux, Tabac, Toxicité.
Wicri :
- topic : Tabac.

English descriptors

KwdEn :
- Animal model, Cigarette, Fumes, Mouse, Nervous system, Neurotoxin, Parkinson disease, Poison interaction, Tobacco, Toxicity.

Abstract

Epidemiological surveys have repeatedly shown that idiopathic Parkinson's disease (PD) occurs less frequently in persons who have smoked cigarettes for many years than among age-matched non-smokers. Since PD might be caused by neurotoxins chemically similar to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we explored the possible protective effect of repeated exposure to cigarette smoke against MPTP neurotoxicity in the C57 black mouse. Mice given MPTP and exposed to cigarette smoke suffered just as great a depletion of striatal dopamine as did mice treated only with MPTP. We discovered also that different lots of C57 black mice obtained from a single supplier can have markedly different sensitivities to MPTP.

Url:

https://api-v5.istex.fr/document/332AC72C922B4212ABDCA4670C8F3F5C768EAF88/fulltext/pdf

DOI: 10.1016/0304-3940(87)90152-2

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Epidemiological surveys have repeatedly shown that idiopathic Parkinson's disease (PD) occurs less frequently in persons who have smoked cigarettes for many years than among age-matched non-smokers. Since PD might be caused by neurotoxins chemically similar to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we explored the possible protective effect of repeated exposure to cigarette smoke against MPTP neurotoxicity in the C57 black mouse. Mice given MPTP and exposed to cigarette smoke suffered just as great a depletion of striatal dopamine as did mice treated only with MPTP. We discovered also that different lots of C57 black mice obtained from a single supplier can have markedly different sensitivities to MPTP.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Exposure to cigarette smoke does not decrease the neurotoxicity of N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

Exposure to cigarette smoke does not decrease the neurotoxicity of N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.